Алла Михайлова on Leukoformula

LP Cells in Nodular Lymphocyte-Predominant Hodgkin Lymphoma

Fri, 01 Sep 2023 08:57:30 +0300

🍿Popcorn cells / LP cells

✅ Found in nodular Hodgkin lymphoma with lymphocyte predominance (it is recommended to use the term nodular lymphocyte-predominant B-cell lymphoma).

✅ This non-classical type of Hodgkin lymphoma occurs in approximately 5% of cases.

Blood Smear Morphology in Primary Myelofibrosis

Mon, 27 Mar 2023 09:00:01 +0300

Peripheral blood smear in myelofibrosis

Myelofibrosis, classified as “primary,” belongs to myeloproliferative neoplasms where fibrosis is reactive to a hematological neoplasm. Secondary myelofibrosis represents a bone marrow stromal reaction to a non-hematological disease, for example, it can occur in cases of carcinoma or sarcoma metastasis to the bone marrow. Both of these variants of myelofibrosis will have a rather similar picture upon examination of peripheral blood smears, with some exceptions, which we will consider in more detail.

Mitotic Figures and Dyserythropoiesis in MDS with Excess Blasts

Sun, 12 Mar 2023 14:30:26 +0300

Clinical case: mitotic figures in myelodysplastic syndrome.

A 64-year-old man was admitted with progressive asthenia and pancytopenia. Complete blood count showed hemoglobin 7.5 g/dL, white blood cell count 1.2 × 10^{9/L, and platelet count 25 × 10}9/L. Bone marrow aspirate revealed 7% myeloblasts and 69% erythroblasts with dysplastic features: cytoplasmic vacuoles, nuclear budding, and multinucleated cells (panels A-D). Mitotic figures were observed in all phases of division in the erythroid lineage, including normal mitotic figures (panels E-H) and abnormal ones (panels I-L). Additionally, some erythroblasts presented with multiple micronuclei (panels M-P). Cytogenetic analysis revealed an abnormal clone: 43∼45,XY,-5,-7,-18,?add(19)(q13.3),+mar1,min[cp20]. The diagnosis of myelodysplastic syndrome (MDS) with excess blasts was confirmed.