Nana Novikova on Leukoformula

Bone Marrow Erythroid Lineage in Multiple Myeloma

Mon, 11 May 2026 08:00:00 +0300

Patient, 71 years old, diagnosed with multiple myeloma.

Complete blood count:

RBC 3.6×10^12/L

HGB 128 g/L

WBC 4.0 g/L

PLT 210×10^9/L

ESR 18 mm/hour.

In the control bone marrow aspirate, after a course of treatment, the erythroid lineage of hematopoiesis is expanded to 47.5% (normal range 14.5-26.5). Binucleated erythrokaryocytes (photo 2, 3) and mitotic figures (photo 5) are observed.

Megakaryocytes in Bone Marrow Aspirate and Thrombopoiesis

Thu, 07 May 2026 08:00:01 +0300

MEGAKARYOCYTES in bone marrow aspirate.

The function of megakaryocytopoiesis is platelet formation.

Up to 5 thousand platelets bud off from each megakaryocyte. The lifespan of platelets is about 10 days.

Emperipolesis in Bone Marrow: Neutrophil in Megakaryocyte

Tue, 05 May 2026 08:00:00 +0300

EMPERIPOLESIS.

The “guest” (neutrophilic granulocyte) embedded in the megakaryocyte can leave the “host” at any time (without changes or consequences for itself).

Thus, ONE CELL PENETRATES ANOTHER, temporarily resides in it, and leaves it without any damage.

Bone Marrow Macrophages: Morphology of Stromal Cells

Mon, 04 May 2026 10:00:02 +0300

BONE MARROW STROMAL CELLS - the diversity of macrophages.

Some macrophages show vacuolization and remnants of phagocytosed material in their cytoplasm.

🙏 The publication was kindly provided by clinical diagnostic laboratory physician Nana Novikova, CHUZ “KB” RZHD-Meditsina, Smolensk.

Marginal Zone Lymphoma: Atypical Lymphocytes in Blood Smear

Sat, 02 May 2026 08:00:01 +0300

B-cell MARGINAL ZONE LYMPHOMA (confirmed). In the patient’s CBC - moderate anemia and thrombocytopenia - RBC 3.65×10^{12/L
HGB 116 g/L,
PLT 100×10}9/L, Leukocytosis, RDW 73.22×10^9/L, with absolute lymphocytosis and neutropenia. In the photographs - ATYPICAL lymphocytes. Receiving treatment.

Myelogram in Suspected Lymphoproliferative Disease

Wed, 29 Apr 2026 08:00:00 +0300

PATIENT is 22 years old. Sternal puncture was prescribed to rule out lymphoproliferative disease.

In peripheral blood - moderate leukocytosis, other parameters are normal.

In the BONE MARROW ASPIRATE, the number of lymphocytes is slightly increased - 22.6% (N 4.3-13.7%), plasma cells 0.6 (N 0.4 - 1.8).

Bone Marrow Erythroid Hyperplasia in Splenomegaly Case

Sat, 25 Apr 2026 08:00:00 +0300

SPLENOMEGALY in a 56-year-old PATIENT. Complete blood count without abnormalities: RBC 4.66×10^{12/L
HGB 142 g/L
WBC 3.43×10}9/L PLT 149 ×10^9/L.

In the bone marrow aspirate, the granulocytic lineage is relatively narrowed (35.4%), lymphocytes are 13.5% (normal 4.3-13.7%), and erythrocaryocyte proliferation is significantly increased (45.0%). Binucleated erythrocaryocytes are observed. Megakaryocytes show preserved functional capacity.

Proerythroblast: Morphological Features of the Cell

Tue, 14 Apr 2026 08:00:00 +0300

PROERYTHROBLAST is a young, large cell of the erythroid lineage of hematopoiesis, with a round nucleus containing delicate reticular chromatin, a nucleolus, and intensely basophilic cytoplasm.

🙏 The publication was kindly provided by KDL physician Nana Novikova, CHUZ “KB” RZHD-Meditsina", Smolensk.

Acute Lymphoblastic Leukemia: Cytochemistry and Blast Morphology

Fri, 10 Apr 2026 10:00:01 +0300

TRILINEAGE cytopenia in a 75-year-old patient. Bone marrow aspirate shows total blast infiltration. The cytoplasm is basophilic with vacuolization. Myeloperoxidase reaction in blasts is negative. PAS reaction is positive in granular form. The morphocytochemical characteristics correspond to lymphoid lineage – a picture of acute lymphoblastic leukemia.

Blasts in Peripheral Blood in Acute Leukemia

Wed, 08 Apr 2026 11:00:00 +0300

BLASTS.

Peripheral blood of a patient with acute leukemia.

🙏 The publication was kindly provided by the clinical diagnostic laboratory physician Nana Novikova, CHUZ “Clinical Hospital” RZHD-Meditsina, Smolensk.

Leukemization of Lymphoma: Atypical Lymphocytes in Blood Smear

Wed, 25 Mar 2026 09:00:01 +0300

A 54-year-old patient from the hematology department, diagnosed with lymphoma.

The complete blood count shows severe anemia, anisocytosis and poikilocytosis of erythrocytes; leukocytosis with lymphocytosis, predominantly represented by abnormal lymphocytes (blasts?), with irregular nuclear shapes, indistinct nucleoli, finely dispersed chromatin, some with vacuolated cytoplasm.

Plasma Cells in Bone Marrow in Multiple Myeloma

Mon, 09 Feb 2026 08:00:01 +0300

The patient was referred for a consultation with a hematologist due to anemia and leukocytosis. Bone marrow was taken, in which the number of plasma cells was increased. At the patient’s next appointment, hospitalization will likely be offered for further examination and treatment of the disease. At this stage, morphologically, multiple myeloma can be suspected.

Blood and Bone Marrow Findings in Chronic Lymphocytic Leukemia

Sat, 15 Nov 2025 09:22:00 +0300

In the patient’s CBC, with a confirmed diagnosis of CLL, leukocytosis (92.9) with absolute lymphocytosis (89%) was observed.

In the bone marrow aspirate, there was tumor infiltration – lymphocytes with clumpy, condensed nuclear chromatin. Cytolysis cells were present.