Oncohematology
Breast Cancer Metastasis to Bone Marrow: Cytology
A clinical case of breast adenocarcinoma metastasis to bone marrow: cytological features, osteoblasts, osteoclasts, and biochemical markers.
Laboratory methods
Alpha-Naphthyl Acetate Esterase Activity in Monoblasts
Evaluating alpha-naphthyl acetate esterase activity in bone marrow smears to identify monocytic lineage cells: monoblast and promonocyte morphology.
Hematology
Endothelial Cells in Bone Marrow Aspirate
How endothelial cells of blood vessels appear in bone marrow aspirate smears: morphological features and differential diagnosis.
Laboratory methods
Sysmex Hematology Analyzer Scattergrams Explained
Schematic diagrams of blood cell population distribution on Sysmex XN and XE series analyzer scattergrams: WDF, WNR, PLT-F, RET, DIFF, and IMI channels.
Hematology
History of Iron Deficiency Anemia and Chlorosis
How iron deficiency anemia was described in the 16th century: chlorosis, maiden's disease, and the first clinical observations by German physician Johannes Lange.
Hematology
Proerythroblast vs. Plasma Cell: Morphological Distinctions
Key criteria for differential diagnosis of proerythroblasts and plasma cells: nuclear location, cytoplasmic basophilia, and N:C ratio.
Oncohematology
Neutrophilic Leukemoid Reaction in Multiple Myeloma
Clinical case of neutrophilic leukemoid reaction in multiple myeloma: neutrophil morphology, Döhle bodies, and differential diagnosis with CNL.
Laboratory methods
Myelogram Cell Count: 300 or 500 Cells in Bone Marrow Smear
How many cells to count for a myelogram: comparing WHO recommendations for 500 cells and data on differentiating 300 bone marrow aspirate cells.
Laboratory methods
Light Microscopy in Clinical Laboratory Diagnostics
The role of light microscopy and the laboratory microscope for a clinical laboratory diagnostics physician in differential leukocyte count and peripheral blood smear evaluation.
Oncohematology
Pawn Ball Megakaryocytes in Myelodysplasia
Explore the morphological features of pawn ball megakaryocytes in myelodysplastic syndrome. Understand the diagnostic significance of dysmegakaryocytopoiesis in bone marrow smears.
Hematology
Bone Marrow as a Hematopoietic Organ: History of Discovery
Explore the history of hematopoiesis: Ernst Neumann's 1868 discovery of bone marrow's role and Mikhail Arinkin's 1928 introduction of in vivo bone marrow puncture.
Hematology
Pinocchio Cells in Blood Smear: Lymphocyte Morphology
Morphological features of Pinocchio cells in blood smears during interleukin-2 therapy. Immunophenotype and cytochemical markers of activated T-lymphocytes.