Laboratory methods
Purified DNA Solution: Causes of High Viscosity
Why purified genomic DNA solutions are highly viscous: physicochemical properties of eukaryotic DNA molecules in the clinical laboratory.
Hematology
LE Cells in Blood Smear: Morphology and Formation
What LE cells are in systemic lupus erythematosus: morphological signs of nuclear material phagocytosis by neutrophils in a blood smear.
Hematology
Secondary Erythrocytosis in Heart Defect: Hemoglobin 258 g/L
A clinical case of severe secondary erythrocytosis in a patient with a heart defect: hemoglobin level 258 g/L, hematocrit 76%, and erythrocytes 7.60×10¹²/L.
Oncohematology
Chronic Neutrophilic Leukemia: Bone Marrow Aspirate
A clinical case of chronic neutrophilic leukemia: hyperleukocytosis, granulocyte hyperplasia, and phagocytosis of nuclear debris by bone marrow macrophages.
Oncohematology
Clinical Case: Splenomegaly and Atypical Lymphocytes
Oncohematology clinical case: patient with splenomegaly, leukocytosis, and atypical lymphocytes in blood smear, BRAF mutation negative. Choose diagnosis.
Hematology
Elevated MCHC in Blood Test: Causes and Algorithm
What to do if MCHC is elevated above 375 g/L in CBC: causes of false elevation, cold agglutination, sample warming, and blood smear evaluation.
Parasitology
Anaplasmosis: Anaplasma phagocytophilum Morulae in Blood Smear
A clinical case of granulocytic anaplasmosis: Anaplasma phagocytophilum morulae found in neutrophils on a blood smear, along with thrombocytopenia and hyponatremia.
Hematology
Hemosiderin in Urine in Paroxysmal Nocturnal Hemoglobinuria
Urine sediment in paroxysmal nocturnal hemoglobinuria: microscopy of hemosiderin clumps in epithelial cells and a hyaline cast during hemolysis.
Clinical cases
Rh Factor and Antibody Misidentification in Transfusion
A clinical case detailing severe consequences of Rh factor and anti-erythrocyte antibody misidentification before blood transfusion, and legal liability.
Hematology
Morphology of Large Granular Lymphocytes in Blood Smear
Morphological features of large granular lymphocytes (LGL) in peripheral blood: cytoplasm with azurophilic granularity on microscopy.
Hematology
Eosinophilic Myelocytes: Cytomorphology in Blood Smears
Morphological features of eosinophilic myelocytes in blood smears: specific orange-pink granularity, nuclear shape, and cytoplasm.
Lab test interpretation
BNP and NT-proBNP in Heart Failure Diagnostics
Reference ranges and cut-off levels for BNP and NT-proBNP in heart failure exclusion and confirmation, and indications for echocardiography.