Laboratory methods

Sysmex XN Analyzer for Effusion Fluid Analysis

Capabilities of the Sysmex XN analyzer in pleural and ascitic fluid analysis. Significance of the HF-BF parameter and the necessity of microscopy in tumors.

Analyzer scattergrams and microscopic preparations of effusion fluid with cells
Analyzer scattergrams and microscopic preparations of effusion fluid with cells

🧪 Analysis of Body Fluids: Automation vs. Microscope

A study showed that the new hematology analyzer Sysmex XN-2000 performs excellently in counting cells in ascitic and pleural fluid and other biomaterials 🧫. In the absence of tumor cells, the automatic mode yields results comparable to manual counting (up to 96% accuracy 🔬).

⚡ However, when cancer is suspected — especially if the number of high-fluorescence cells (HF-BF) exceeds 6.9 per 100 leukocytes — mandatory microscopy is necessary! Otherwise, important changes can be missed 🧠.

📈 HF-BF cells are more common in malignant processes, but reactive cells (e.g., macrophages) can also give a false-positive result.

💬 Conclusion: Automation speeds up routine diagnostics, but for detecting tumor cells, the expert’s eye remains indispensable! 👁‍🗨 👉 Source: 🩸 The full article from the international journal of laboratory hematology is available in the library of blood and bone marrow secrets.