Pelger-Huët Anomaly: Blood Smear Morphology

A clinical case of hereditary Pelger-Huët anomaly. Morphological features of neutrophil nuclear hyposegmentation in peripheral blood.

Vera Kirnas 1 min December 20, 2024

Blood smear: neutrophil with a rounded unsegmented nucleus in Pelger-Huët anomaly

Blood smear: neutrophil with a characteristic bilobed pince-nez shaped nucleus

Blood smear: neutrophil with a dumbbell-shaped nucleus and condensed chromatin

Blood smear: hyposegmented neutrophil with coarse chromatin structure

Blood smear: mature neutrophil with a monolobar round nucleus

Blood smear: bilobed neutrophil, typical for Pelger-Huët anomaly

🔬 The patient has no complaints. This blood picture is also observed in some members of his family. What thoughts came to mind?

🙏 The clinical case was kindly provided by Vera Kirnas, KDL Biologist, F.S. Ankudinov Yuzhno-Sakhalinsk City Hospital.

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