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Oncohematology

Atypical Blast Nuclei Morphology in a Blood Smear

Clinical case analyzing blast morphology in a blood smear: identifying deep clefts, nuclear lobulation, binuclearity, and chromatin structure assessment.

Evgeny Zaytsev Evgeny Zaytsev 1 min
Blood smear, blast cell with deep nuclear indentation and nucleolus
Blood smear, blast cell with deep nuclear indentation and nucleolus
Blood smear, blasts with characteristic deep longitudinal nuclear clefts
Blood smear, blasts with characteristic deep longitudinal nuclear clefts
Blood smear, blast with a deep median cleft simulating binuclearity
Blood smear, blast with a deep median cleft simulating binuclearity
Blood smear, binucleated blast with characteristic delicate chromatin pattern
Blood smear, binucleated blast with characteristic delicate chromatin pattern
Blood smear, mononuclear blast with delicate reticular chromatin distribution
Blood smear, mononuclear blast with delicate reticular chromatin distribution
Blood smear, a pair of blast cells with moderately basophilic cytoplasm and nuclear atypia
Blood smear, a pair of blast cells with moderately basophilic cytoplasm and nuclear atypia
Blood smear, cluster of three blasts with pronounced nuclear polymorphism and nucleolus
Blood smear, cluster of three blasts with pronounced nuclear polymorphism and nucleolus
Blood smear, large blast with irregular nuclear contour and basophilic cytoplasm
Blood smear, large blast with irregular nuclear contour and basophilic cytoplasm

Blasts, 68-year-old female. The morphology of blast nuclei can be quite diverse. In this case, we see cuts, clefts, nuclear deformity, and binuclearity of blasts. I remind you that the main distinguishing feature of blasts is not their shape, but the delicate reticular chromatin structure of the nucleus.

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