Hematology

Blister Cells and Pyknocytes: Erythrocyte Morphology

Morphological features of blister cells (pyknocytes) in a blood smear. Causes of appearance in G6PD deficiency, infections, and pyknocytosis.

Blood smear: blister cell (blister erythrocyte), indicated by arrow
Blood smear: blister cell (blister erythrocyte), indicated by arrow

Blister cell or Pyknocyte (blister erythrocyte). ❗Occurs not only in patients with G6PD deficiency, but also in children with viral infections and a rare neonatal disease - infantile pyknocytosis. Photo source: Anderson - Atlas of Hematology, 2007