❗A 55-year-old woman, Rosai-Dorfman Disease. 🔬Cervical lymph node imprint smear.
✅Rosai-Dorfman disease is a histiocytosis characterized by nodal or extranodal proliferation of large histiocytes/macrophages with signs of emperipolesis. Intact hematopoietic cells (most often lymphocytes, less often plasma cells, neutrophilic granulocytes, erythrocytes) are present in the cytoplasm of histiocytes. S-100, Oct2, and cyclin D1 expression is detected in histiocytes with emperipolesis. The surrounding area is dominated by small mature lymphocytes and numerous polytypic plasma cells.
👉The images were kindly provided by Clinical Laboratory Diagnostics physician, Pathologist from St. Petersburg Elena Alexandrovna Belyakova, Department of Molecular Morphology, E.E. Eichwald Clinic (Center for Differential Diagnosis of Lymphomas), I.I. Mechnikov Northwestern State Medical University.
