Ascites Cytology in Signet-Ring Cell Adenocarcinoma

Cytological findings in ascitic fluid from a patient with signet-ring cell adenocarcinoma: atypical cell clusters, eccentric nuclei, and elevated CA 125.

Editorial team 1 min September 6, 2024

Collage of microphotographs of ascitic fluid smear in adenocarcinoma

Cytological preparation: signet-ring cell within a tumor cluster

Ascitic fluid smear: large vacuole displacing the nucleus to the periphery

Ascitic fluid smear: giant mucinous cell and atypical nuclei

Cytological preparation: pronounced polymorphism and cytoplasmic vacuolization

Ascitic fluid smear: dense cluster of atypical glandular cells

Cytological preparation: various-sized adenocarcinoma cells in ascites

Ascitic fluid smear: two compact complexes of tumor cells

Cytological preparation: large papillary complex of cancer cells

Ascitic fluid smear: small group of cells with signs of atypia

🔬 Ascitic fluid cytology from a 55-year-old woman with ascites. ❗Adenocarcinoma with signet-ring cells

✅ The smear shows densely packed clusters of malignant cells with large pleomorphic nuclei. Several large mucinous cells show vacuolated cytoplasm and peripherally displaced nuclei. 👉 The patient’s tumor marker CA 125 was 2150 units/mL.

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