Laboratory methods

Thyroid Hurthle Cell Neoplasm Cytology: Key Diagnostic Features

Explore the morphological criteria for Hurthle cell neoplasms in thyroid cytology, focusing on oncocyte characteristics and the malignancy risk of cytological findings.

Cytological preparation: clusters of Hurthle cells with granular cytoplasm
Cytological preparation: clusters of Hurthle cells with granular cytoplasm

Thyroid cytology. The presented cytological preparation shows a Hurthle cell neoplasm. The cells are characterized by abundant granular cytoplasm and centrally located nuclei, which may contain prominent nucleoli.

Note:

  • This morphological picture is consistent with a Hurthle cell neoplasm; however, a definitive conclusion regarding benignity or malignancy requires histological confirmation.
  • In 15–45% of cases, a cytological picture suspicious for a Hurthle cell neoplasm turns out to be malignant.

Source: M. Sheaff, N. Singh – Cytopathology: An Introduction (2013). 💎 Find even more useful materials on cytology in our LAB-TESTS library. The link with access to the library is automatically sent to you via private message after paying for a VK Donut Labformula subscription.