Lab test interpretation

Herpes Virus Cytopathic Effect in Cervical Smear

Morphological features of Herpes simplex virus (HSV) in cervical cytology: multinucleation, nuclear molding, and intranuclear inclusions.

Cervical cytological smear: cell with nuclear molding in herpes
Cervical cytological smear: cell with nuclear molding in herpes

Multinucleated epithelial cell in herpesvirus infection.

Morphological features:

  • Presence of multiple nuclei with the phenomenon of “molding” (close apposition of nuclei to each other without clear boundaries).
  • Basophilic intranuclear inclusions, separated from the thickened nuclear membrane by a clear zone (perinuclear halo).

Context: This image illustrates the cytopathic effect of Herpes simplex virus in cervical epithelial cells.

Source: M.Sheaff, N.Singh - Cytopathology An Introduction - 2013.