Hematology

G6PD Deficiency: Degmacytes in Blood Smear During Hemolysis

A clinical case of post-vaccination hemolysis: a sharp drop in hemoglobin, degmacytes and eccentrocytes in a peripheral blood smear in G6PD deficiency.

A clinical case from Israel 🇮🇱.

A 70-year-old patient. Hemoglobin dropped from 103 to 75 g/L within 24 hours. Reticulocytes 13.1%. LDH 634 (0-248). Bilirubin 8.47 (0.3-1.2). Haptoglobin <10 (30-200). He received a flu vaccination a few days ago. No similar manifestations were noted in his history, but the diagnosis was established in close relatives. What changes do we see in red blood cells? What is the diagnosis?

🙏 The case was kindly provided by the Head of the Morphology/IFT Department of the Ha-Emek Medical Center Laboratory in Afula, Israel - Anna Belen.

❗ The first 3 people to answer correctly in the comments will receive an invitation to the closed club of laboratory hematologists.