Oncohematology

Dendritic Cell Neoplasm: Bone Marrow Cell Morphology

A clinical case of agranulocytosis in a young female patient: cytopenic syndrome and atypical blast cells in a bone marrow smear, with suspicion of BPDCN.

❗ A young woman was admitted with agranulocytosis. Laboratory parameters on admission:

🩸 CBC: Hemoglobin — 85 g/L Red blood cells — 2.7×10¹²/L White blood cells — 0.7×10⁹/L Platelets — 221×10⁹/L

🦴 The cells shown in the images below were found in the bone marrow aspirate. The patient was referred to Moscow to rule out dendritic cell neoplasm.

🙏 Images kindly provided by biologist Ksenia Puchkova, Clinical Diagnostic Laboratory, Rostov-on-Don