What is a dicentric (dic) in cytogenetics? Structural features of a dicentric chromosome with two centromeres and translocation mechanisms.
❗A dicentric (dic) is a chromosome that has two centromeres and resulted from a reciprocal translocation of two chromosomes.
Cytogenetic study and karyotyping: detection of t(9;22) translocation in CML and trisomy 21 on metaphase plates.
Steps for preparing chorionic villus cells for karyotyping: hypotonia, colchicine treatment, mechanical cytolysis, and metaphase plate staining.
Exploring reflexive testing in hematopathology: ordering additional tests, ethics, consent, and legal risks. A look into current practices.
