Hematology

Plasmocyte vs. Macrophage Differentiation in Bone Marrow

Clinical case of bone marrow aspirate analysis from a 45-year-old male: differential diagnosis between a plasma cell and a macrophage on microscopy.

Bone marrow smear: large cell with eccentric nucleus and blue cytoplasm
Bone marrow smear: large cell with eccentric nucleus and blue cytoplasm

❗ Cytology challenge! Is the image a plasma cell or a macrophage? 🔬 Bone marrow aspirate from a 45-year-old male. Hemoglobin 78 g/L. Platelets 123 thousand/µL. Leukocytes 11.7 thousand/µL.

👉 Image kindly provided by Zebiniso Kholmuradova, morphologist, Uzbekistan, Kashkadarya Multidisciplinary Children’s Medical Center.