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Oncohematology

Blast vs. Atypical Lymphocyte Differentiation in Blood Smear

A 51-year-old patient presented with hyperleukocytosis (161×10⁹/L). This case explores the morphological differential diagnosis of blasts and atypical lymphocytes in a blood smear.

Vadim Jankulov Vadim Jankulov 1 min
Blood smear: atypical mononuclear cell surrounded by mature neutrophils
Blood smear: atypical mononuclear cell surrounded by mature neutrophils
Blood smear: cell with loose chromatin, nucleolus, and a narrow rim of basophilic cytoplasm
Blood smear: cell with loose chromatin, nucleolus, and a narrow rim of basophilic cytoplasm
Blood smear: immature cell with blast morphology next to a segmented neutrophil
Blood smear: immature cell with blast morphology next to a segmented neutrophil
Blood smear: large mononuclear cell with visible nucleolus and surrounding neutrophils
Blood smear: large mononuclear cell with visible nucleolus and surrounding neutrophils
Blood smear: cell with high nuclear-cytoplasmic ratio and granulocytes
Blood smear: cell with high nuclear-cytoplasmic ratio and granulocytes
Blood smear: two immature cells with basophilic cytoplasm and mature neutrophils
Blood smear: two immature cells with basophilic cytoplasm and mature neutrophils
Blood smear: atypical cell, disintegrated leukocyte, and segmented neutrophils
Blood smear: atypical cell, disintegrated leukocyte, and segmented neutrophils
Blood smear: granulocyte with abundant granulation and a mononuclear cell
Blood smear: granulocyte with abundant granulation and a mononuclear cell
Blood smear: pronounced leukocytosis with a left shift and immature cells
Blood smear: pronounced leukocytosis with a left shift and immature cells

Patient 51 years old. Blasts or atypical lymphocytes?! In CBC: Leukocytes - 16110⁹/L Neutrophils - 12210⁹/L Monocytes - 2310⁹/L Platelets - 47310⁹/L HGB - 106 g/L

🙏 The publication was kindly provided by laboratory assistant Vadim Jankulov Kazakhstan, Ust-Kamenogorsk.

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