Distinguishing Prolymphocytes from Blasts in CLL

A clinical case of marked leukocytosis in CLL. Morphological criteria for differentiating prolymphocytes from blast cells in a peripheral blood smear.

Татьяна Шаптала 1 min November 14, 2023

Blood smear: marked lymphocytosis, mature lymphocytes and cells with large nucleoli

Blood smear: lymphoid cells with features of prolymphocytes, nucleoli visible

Blood smear: lymphocytes and atypical mononuclear cells with chromatin condensation and a nucleolus

Blood smear: predominance of prolymphocyte-like cells with a moderate rim of cytoplasm

⚠️Urgent help is needed for our subscriber! ✅Blasts or prolymphocytes in a blood smear? Hello colleagues! Please help with this patient! A 80-year-old woman. Hemoglobin 99 g/L, Platelets 79 thousand/µL, Leukocytes 171.8 thousand/µL. →According to her daughter, she has a history of CLL (chronic lymphocytic leukemia). Opinions with colleagues are completely divided (Thank you in advance🙏