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Oncohematology

Differential Diagnosis of Marked Lymphocytosis

Clinical case of an 84-year-old female patient: leukocytosis 340×10⁹/L, Botkin-Gumprecht shadows, peripheral blood and bone marrow aspirate smears.

Anna Belen Anna Belen 1 min
Hematology analyzer printout: leukocytes 339.9 K/ul
Hematology analyzer printout: leukocytes 339.9 K/ul
Peripheral blood smear: marked lymphocytosis and Gumprecht shadows
Peripheral blood smear: marked lymphocytosis and Gumprecht shadows
Peripheral blood smear: lymphocyte clusters and cellular debris
Peripheral blood smear: lymphocyte clusters and cellular debris
Peripheral blood smear: disrupted lymphoid cells in the preparation
Peripheral blood smear: disrupted lymphoid cells in the preparation
Peripheral blood smear: Botkin-Gumprecht shadows and mature lymphocytes
Peripheral blood smear: Botkin-Gumprecht shadows and mature lymphocytes
Peripheral blood smear: proliferation of atypical lymphoid cells
Peripheral blood smear: proliferation of atypical lymphoid cells
Bone marrow smear: diffuse infiltration by monomorphic lymphocytes
Bone marrow smear: diffuse infiltration by monomorphic lymphocytes

🔬Clinical case from a doctor from 🇮🇱Israel - Anna Belen 👉We suggest considering the diagnosis, given the peripheral blood test data (leukocytosis 340×10^9/L!), blood smears, and bone marrow aspirate from an 84-year-old female patient. ✅Immunophenotyping and the final answer - we will publish later!

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