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Oncohematology

Dyserythropoiesis and Bone Marrow Hypoplasia in Pancytopenia

A clinical case review of severe pancytopenia: hypocellular bone marrow, erythroblastic islands, signs of dyserythropoiesis, and mitoses in aspirate.

Darya Todzhaeva Darya Todzhaeva 1 min
Bone marrow smear: erythroblastic island against a background of adipocytes
Bone marrow smear: erythroblastic island against a background of adipocytes
Bone marrow smear: cluster of adipocytes and single normoblasts
Bone marrow smear: cluster of adipocytes and single normoblasts
Bone marrow smear: stromal macrophage with phagocytosed material
Bone marrow smear: stromal macrophage with phagocytosed material
Bone marrow smear: basophilic normoblasts with signs of atypia
Bone marrow smear: basophilic normoblasts with signs of atypia
Bone marrow smear: basophilic normoblast and large reticular element
Bone marrow smear: basophilic normoblast and large reticular element
Bone marrow smear: promyelocyte and maturing normoblasts in aspirate
Bone marrow smear: promyelocyte and maturing normoblasts in aspirate
Bone marrow smear: binucleated oxyphilic normoblast and lymphocyte
Bone marrow smear: binucleated oxyphilic normoblast and lymphocyte
Bone marrow smear: monocytoid cell with irregular cytoplasmic contours
Bone marrow smear: monocytoid cell with irregular cytoplasmic contours
Bone marrow smear: mitotic figure of a hematopoietic cell in aspirate
Bone marrow smear: mitotic figure of a hematopoietic cell in aspirate
Bone marrow smear: binucleated normoblast as a marker of dyserythropoiesis
Bone marrow smear: binucleated normoblast as a marker of dyserythropoiesis

Woman, 61 years old, with pancytopenia in CBC: WBC - 0.3 K/µL, RBC - 2.0 M/µL, PLT - 15 K/µL. Bone marrow cellularity is sharply reduced; the first two photos show one of the few erythroblastic islands in the material, adipocytes. Further, a macrophage, mitotic figures, binucleated normoblasts. What is your opinion, colleagues?

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