Lab test interpretation
Macrophages in Urine Sediment with Hemolytic Anemia
A clinical case of macrophages found in the urine sediment of a child with hemolytic anemia. Microscopy of native preparation and erythrocyte detritus.
Articles
Blood and bone marrow morphology, clinical cases and diagnostic algorithms. Most of the library is in Russian; the English section is growing.
Most of our material is written in Russian — that is the working language of the community. A few pieces exist in English; the rest of the library is one click away and the photographs need no translation.
Oncohematology
Granular Blasts vs. Dysplastic Promyelocytes in MDS Morphology
IWGM-MDS criteria for differentiating granular blasts and dysplastic promyelocytes: evaluating the Golgi zone, chromatin, and granularity.
Hematology
Pinocchio Cells in Blood Smear: Lymphocyte Morphology
Morphological features of Pinocchio cells in blood smears during interleukin-2 therapy. Immunophenotype and cytochemical markers of activated T-lymphocytes.
Hematology
Bone Marrow as a Hematopoietic Organ: History of Discovery
Explore the history of hematopoiesis: Ernst Neumann's 1868 discovery of bone marrow's role and Mikhail Arinkin's 1928 introduction of in vivo bone marrow puncture.
Oncohematology
Pawn Ball Megakaryocytes in Myelodysplasia
Explore the morphological features of pawn ball megakaryocytes in myelodysplastic syndrome. Understand the diagnostic significance of dysmegakaryocytopoiesis in bone marrow smears.
Laboratory methods
Light Microscopy in Clinical Laboratory Diagnostics
The role of light microscopy and the laboratory microscope for a clinical laboratory diagnostics physician in differential leukocyte count and peripheral blood smear evaluation.
Laboratory methods
Myelogram Cell Count: 300 or 500 Cells in Bone Marrow Smear
How many cells to count for a myelogram: comparing WHO recommendations for 500 cells and data on differentiating 300 bone marrow aspirate cells.
Oncohematology
Neutrophilic Leukemoid Reaction in Multiple Myeloma
Clinical case of neutrophilic leukemoid reaction in multiple myeloma: neutrophil morphology, Döhle bodies, and differential diagnosis with CNL.
Hematology
Platelet Formation and Fate of Mature Megakaryocyte Nucleus
How blood platelets are formed: a diagram of megakaryocyte cytoplasm fragmentation and phagocytosis of its residual nucleus by bone marrow macrophages.
Hematology
Proerythroblast vs. Plasma Cell: Morphological Distinctions
Key criteria for differential diagnosis of proerythroblasts and plasma cells: nuclear location, cytoplasmic basophilia, and N:C ratio.
Hematology
History of Iron Deficiency Anemia and Chlorosis
How iron deficiency anemia was described in the 16th century: chlorosis, maiden's disease, and the first clinical observations by German physician Johannes Lange.
Laboratory methods
Sysmex Hematology Analyzer Scattergrams Explained
Schematic diagrams of blood cell population distribution on Sysmex XN and XE series analyzer scattergrams: WDF, WNR, PLT-F, RET, DIFF, and IMI channels.