Hematology

Emperipolesis and Reactive Bone Marrow Changes

Clinical case: bone marrow morphology in subfebrile temperature and anemia. Granulocytic hyperplasia, platelet aggregates, and emperipolesis.

Patient referred to a hematologist due to moderate anemia; subfebrile temperature for about a month.

Bone marrow aspirate shows moderately expanded granulocytic lineage (70%), with a predominance of mature forms (M:E ratio - 0.4).

Erythroid lineage is reduced - 6.8%, erythropoiesis is normoblastic.

The number of megakaryocytes is increased; megakaryocytes with engulfed cells (emperipolesis) are observed. Many large aggregates of platelets are present (excessive platelet shedding).

Can reactive bone marrow changes against the background of an infectious process be assumed? The patient is being examined by a hematologist.

🙏 The publication was kindly provided by the laboratory diagnostics physician Nana Novikova, CHUZ “Clinical Hospital” RZD-Meditsina, Smolensk.