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Oncohematology

Canine Hemophagocytic Histiocytic Sarcoma: Cytology

Clinical case of canine hemophagocytic histiocytic sarcoma: cytology of lymph node and bone marrow, erythrophagocytosis, anemia, and thrombocytopenia.

Olga Belozerova Olga Belozerova 1 min
Lymph node aspirate cytology: atypical histiocytes with signs of hemophagocytosis
Lymph node aspirate cytology: atypical histiocytes with signs of hemophagocytosis
Lymph node aspirate cytology: multinucleated histiocyte with signs of erythrophagocytosis
Lymph node aspirate cytology: multinucleated histiocyte with signs of erythrophagocytosis
Lymph node aspirate cytology: large histiocyte among polymorphic lymphoid cells
Lymph node aspirate cytology: large histiocyte among polymorphic lymphoid cells
Lymph node aspirate cytology: neoplastic histiocyte, erythrophagocytosis, and mitotic figure
Lymph node aspirate cytology: neoplastic histiocyte, erythrophagocytosis, and mitotic figure
Bone marrow smear cytology: megakaryocyte and erythroid hyperplasia
Bone marrow smear cytology: megakaryocyte and erythroid hyperplasia
Bone marrow smear cytology: multinucleated neoplastic histiocyte and normoblasts
Bone marrow smear cytology: multinucleated neoplastic histiocyte and normoblasts
Bone marrow smear cytology: active hemophagocytosis by a large atypical histiocyte
Bone marrow smear cytology: active hemophagocytosis by a large atypical histiocyte
Bone marrow smear cytology: cluster of erythrocaryocytes and a macrophage with phagocytosis
Bone marrow smear cytology: cluster of erythrocaryocytes and a macrophage with phagocytosis
Bone marrow smear cytology: marked cell pleomorphism and cytoplasmic vacuolization
Bone marrow smear cytology: marked cell pleomorphism and cytoplasmic vacuolization
Bone marrow smear cytology: atypical histiocyte with phagocytized erythrocytes
Bone marrow smear cytology: atypical histiocyte with phagocytized erythrocytes

🔬 Hemophagocytic Histiocytic Sarcoma in a Dog: Lymph Node and Bone Marrow Cytology 📍 Clinical Case: Mixed-breed dog, female, 7 years old. Moderate regenerative anemia and moderate thrombocytopenia. 🧪 Cytology: First 4 photos — mesenteric lymph node aspirate. Next 6 photos — bone marrow biopsy. 🧫 Conclusion: 📌 Hemophagocytic histiocytic sarcoma in both locations. 📌 Bone marrow: marked erythroid hyperplasia (ineffective) and megakaryocytic hyperplasia. 📌 Thrombocytopenia of non-central origin.

🔍 Other features: Blood smear examination revealed isolated macrophages with signs of erythrophagocytosis. ❗ No blood parasite infections detected.

🙏 Case kindly provided by - Olga Belozerova, clinical pathologist, head of the laboratory at the veterinary clinic “Noah’s Ark”, Kirov.

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