Hematology

Langhans Giant Cells in Lymph Node Cytology

Morphological features of Pirogov-Langhans giant cells in lymph node cytological examination in tuberculosis and mycobacterial infections.

Cytological preparation of a lymph node aspirate: Langhans type giant cell
Cytological preparation of a lymph node aspirate: Langhans type giant cell

❗Tuberculosis and other mycobacterial infections are among the most common causes of pathological lymph node enlargement in developing countries. ✅Cytological examination of the lymph node may show a varied mixture of neutrophils, and usually several Langhans giant cells are found. These are large cells with peripherally arranged round or oval nuclei, forming a horseshoe or wreath pattern. 🔬In the photo: Langhans giant cell with a horseshoe-shaped nucleus located at the periphery.

👉Source: M.Sheaff, N.Singh - Cytopathology An Introduction - 2013