Morphological changes in bone marrow during parvovirus B19 infection: rare giant quadrinucleated proerythroblasts with viral inclusions in the nucleus.
🔬 Bone marrow aspirate smear from a patient with parvovirus B-19 infection, demonstrating an extremely rare finding — quadrinucleated giant proerythroblasts with nuclear inclusions (short arrow) and cytoplasmic protrusions — so-called “ears” (long arrow); Wright-Giemsa stain
Source: imagebank hematology. Author: Anurag Singh, MD; Ram Nawal Rao, MD
Bone marrow morphology in parvovirus B19 infection: characteristics of giant proerythroblasts, erythropoiesis features, and laboratory diagnostics.
Hematology diagnostic exercise: identify the disease based on bone marrow morphology, pruritus, flushing, and splenomegaly in a 45-year-old patient.
Morphological features of proerythroblasts (pronormoblasts): size, cytoplasmic basophilia, chromatin structure, and differentiation in bone marrow.
