Morphology of a hypersegmented neutrophil (pleokaryocyte) in a peripheral blood smear in vitamin B12 deficiency. May-Grünwald-Giemsa stain.
Peripheral blood smear from a patient with vitamin B12 deficiency, showing a large hypersegmented neutrophil (pleokaryocyte).
Sample type: Peripheral blood.
Staining type: May-Grünwald-Giemsa.
Authors: E. Triana, M. Monsalve, C. da Silva.
Workplace: Hospital del Mar, Barcelona.
What hypersegmentation of neutrophils in a blood smear means: diagnostic criteria, connection to B12 and folate deficiency, and granulocyte morphology.
Criteria for neutrophil hypersegmentation in blood smears. Diagnostic significance in vitamin B12 deficiency, folic acid deficiency, MDS, and other pathologies.
A clinical case of severe anemia (Hb 35 g/L): marked hypochromia, anisopoikilocytosis, basophilic stippling, Howell-Jolly bodies, and neutrophil hypersegmentation.
