What neutrophil hypogranulation in a blood smear means: diagnostic significance in severe infections and myelodysplastic syndrome (MDS).
🔬 Hypogranulation. It means a decrease in the appearance of normal granulation. Hypogranulation can occur in benign conditions, such as severe infection, as well as in malignant processes, such as MDS.
🙏 Photos and description were kindly provided by biologist Anna Feditskaya, Luhansk.
Morphological features of the granulocytic series: from blast and promyelocyte to mature segmented neutrophil in a blood smear under the microscope.
Criteria for neutrophil hypersegmentation in blood smears. Diagnostic significance in vitamin B12 deficiency, folic acid deficiency, MDS, and other pathologies.
Laboratory criteria for neutrophil hypersegmentation in a complete blood count: hereditary forms, megaloblastic anemia, and the impact of cytostatic therapy.
