Impact of cold autoimmune hemolytic anemia on analyzer parameters: erythrocyte agglutination, false MCHC, and correction by warming at 37 °C.
🔬 This is what the blood of a patient with cold AIHA looks like — erythrocytes literally “clumped together”. In unstained smears, there is pronounced agglutination. 📍Patient, 73 years old, hematology department. ❄ Before incubation, the analyzer showed absurd values: RBC — 0.42, MCHC — almost 2000 g/L!
🔥 After warming at 37 °C, everything normalized — RBC increased to 3.23 × 10¹²/L, MCHC decreased to 326 g/L.
🙏 Photos and description were kindly provided by biologist Anna Feditskaya, Luhansk.
Assessment of normoblastosis in CBC: over 100 normoblasts per 100 leukocytes, hematology analyzer scattergram, and blood smear morphology in anemia.
Impact of cold agglutination on CBC parameters: falsely elevated MCHC, spurious erythrocytopenia, and correction by warming to 37 °C.
Blood analysis and smear microscopy of an ICU patient: neutrophilic leukocytosis, anemia, normoblasts, and large platelets in critical condition.
