Chronic neutrophilic leukemia (CNL). The leukocyte count in this patient was 57 × 10^9/L, with 91% segmented and band neutrophils and 4% neutrophilic myelocytes. There was no anemia or thrombocytopenia. Thorough clinical and radiological examinations did not reveal any underlying disease; cytogenetic and molecular analyses showed no abnormalities. In the bone marrow aspirate, in addition to granulocytic hyperplasia with a preserved maturation curve and 3% blast cells, numerous macrophages with cytoplasm packed with nuclear debris are found.
Chronic Neutrophilic Leukemia: Bone Marrow Aspirate
A clinical case of chronic neutrophilic leukemia: hyperleukocytosis, granulocyte hyperplasia, and phagocytosis of nuclear debris by bone marrow macrophages.
