Examination of cerebrospinal fluid in a 42-year-old man.
🔬 Microscopic examination of the cerebrospinal fluid shows large and pleomorphic lymphoma cells, which have large irregularly shaped nuclei with open chromatin and one or more prominent nucleoli. The cytoplasm is abundant and densely basophilic. 🎨 Staining: Diff-Quick, 1000×
✅ Patient’s diagnosis: Secondary CNS involvement in ALK-negative anaplastic large cell lymphoma. Stage IV. Chemotherapy with CHOEP (cyclophosphamide, doxorubicin, etoposide, vincristine, and prednisone) was promptly initiated. After two cycles, he achieved complete remission.
👉Source: Major, A., Pan, Z. and Kamdar, M. (2017), Secondary CNS involvement of ALK-negative anaplastic large cell lymphoma. Am J Hematol, 92: 1267-1268.
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