🔬PINOCCHIO CELLS ✅Such lymphocytes are observed in the blood during high-dose interleukin-2 therapy in oncology. They show azurophilic granulation in the cytoplasmic processes (and often in the rest of the cytoplasm). Therefore, they were given the aforementioned name. ✅These “noses” of cytoplasmic protrusions serve to bind to tumor cells, followed by cellular lysis of the tumor. ✅Immunophenotypically, this is a CD3-positive T-cell population. ✅Pinocchio cells are cytochemically positive for acid phosphatase and α-naphthyl esterase in a blood smear. ❓In what other conditions can PINOCCHIO CELLS be seen?
Pinocchio Cells in Blood Smear: Lymphocyte Morphology
Morphological features of Pinocchio cells in blood smears during interleukin-2 therapy. Immunophenotype and cytochemical markers of activated T-lymphocytes.
