Oncohematology

Sezary Cells: Nuclear Morphology and Blood Smear Diagnosis

Morphological features of Sezary cells in blood smears: cerebriform nuclei, the role of UV radiation in pathogenesis, and principles of PUVA therapy.

Blood smear: atypical lymphocytes with cerebriform nuclei (Sezary cells)
Blood smear: atypical lymphocytes with cerebriform nuclei (Sezary cells)

🔬Sezary cells. Look closely at the cerebriform nuclei of these cells - 🧠! The new 2022 WHO edition indicated a recently discovered etiology for this disease: prolonged environmental UV radiation exposure is a key causative factor in the transformation of skin T-lymphocytes. ✅Strangely enough, this disease is treated with UV radiation (PUVA therapy). 🤜🤛It turns out that “like cures like”!