Oncohematology

Sézary Cells in Blood Smear: A Guide to Identification

Explore the morphological features of Sézary cells: T-lymphocytes with cerebriform nuclei found in peripheral blood in cutaneous T-cell lymphoma and Sézary syndrome.

Blood smear: Sézary cells with characteristic cerebriform nuclei
Blood smear: Sézary cells with characteristic cerebriform nuclei

Sézary syndrome is a cutaneous T-cell lymphoma characterized by lymphadenopathy, erythroderma, and the presence of neoplastic T-lymphocytes with “cerebriform” nuclei (Sézary cells) in the peripheral blood and bone marrow. The nuclei occupy most of the cell, are heterogeneous, with a convoluted chromatin structure, and usually lack nucleoli.