Hematology

Clinical Case: Diagnosing Severe Eosinophilia

A 43-year-old man with hepatosplenomegaly and eosinophilia of 11,000/µL. Solve the clinical problem: what test is needed to clarify the diagnosis?

Peripheral blood smear for the differential diagnosis exercise
Peripheral blood smear for the differential diagnosis exercise

💡 Exercise from the closed club of laboratory hematologists.

Clinical case: A 43-year-old man presented with complaints of chest pain, general weakness, itching, and cough, which have bothered him for a year. Objectively, hepatosplenomegaly was found. Blood analysis showed: total leukocytosis 17,400/µL, absolute eosinophil count 11,000/µL, hemoglobin 145 g/L, platelets 156,000/µL. A peripheral blood smear demonstrated an increased number of eosinophils and their precursors. Bone marrow biopsy revealed hypercellularity with an increased number of eosinophilic precursors.

❓What test is necessary to clarify the diagnosis? ANSWER OPTIONS: A) BCR-ABL transcript test B) 4q deletion test C) 5q deletion test D) Options A and B E) All options (A, B, and C)

The first 3 people who answer correctly in the comments will receive an invitation to the closed club. ANSWER TOMORROW!