💡 An exercise from the Closed Club of Laboratory Hematologists. Identify the most likely disease based on the clinical and morphological picture.
Myelogram of a 45-year-old patient: numerous large cells in the bone marrow with round/oval nuclei, dense chromatin, and abundant cytoplasm filled with large granules, partially masking the nucleus.
Clinically: chronic skin pruritus, episodes of urticaria and flushing (redness of the face and neck), periodic abdominal pain, splenomegaly.
Which diagnosis is most likely?
A. Chronic myeloid leukemia, basophilic-eosinophilic variant B. Systemic mastocytosis C. Acute promyelocytic leukemia D. Reactive eosinophilia The first 3 people who answer correctly in the comments will receive an invitation to the closed club. CORRECT ANSWER TOMORROW!
