Oncohematology

Bone Marrow in Multiple Myeloma Remission: A Case Study

Evaluating bone marrow aspirate in multiple myeloma remission: mature plasma cell morphology, absence of atypia, and normal myelogram parameters.

🔬 Multiple Myeloma. Remission under the microscope.

In a 74-year-old patient with multiple myeloma in remission, the bone marrow picture appears calm and convincing.

In the bone marrow aspirate, the lymphoid lineage is not expanded. The total content of lymphocytes and plasma cells is 10.5%:

  • lymphocytes — within reference range (4.3–13.7%),
  • plasma cells — without signs of pathological expansion (normal 0.1–1.8%).

Complete blood count — no abnormalities.

In photos 1 and 2 — a mature plasma cell: a distinct eccentrically located nucleus, characteristic “cartwheel” chromatin structure, pronounced basophilic cytoplasm with a perinuclear clear zone. The morphology is calm, with no signs of atypia.

This picture corresponds to morphological remission of the disease.

🙏 The publication was kindly provided by clinical laboratory physician Nana Novikova, CHUZ “KB” RZHD-Meditsina" Smolensk.