Oncohematology

Crystalline Inclusions in Myeloma Plasma Cells

Clinical case of multiple myeloma: an atypical plasma cell with crystalline needle-like inclusions in a bone marrow smear.

Bone marrow smear: plasmacyte with needle-like crystalline inclusions
Bone marrow smear: plasmacyte with needle-like crystalline inclusions

Plasma cells with cytoplasmic needle-like inclusions

Clinical information: Female, 71 years old. Former smoker with arterial hypertension, dyslipidemia, hypothyroidism, and chronic renal failure with a three-year history. Chronic pain in the left hip.

Biological information: Complete blood count normal. Creatinine 1.52 mg/dL. Glomerular filtration rate 34 mL/min. Calcium 10.9 mg/dL. IgA 3331 mg/dL. Monoclonal IgA kappa component 3.12 g/dL. Free light chains kappa 1560 mg/dL, free light chains lambda 9.6 mg/dL, kappa/lambda free light chain ratio 162.5. Protein in 24-hour urine 1675 mg/dL.

Sample type: Bone marrow. Staining type: May-Grünwald-Giemsa. Author: González Díaz, Laura. Workplace: Hospital Universitario Virgen de la Victoria.