Hematology

Blood Chimerism: Blood Group Phenotyping

What is blood chimerism? Learn about the causes of a dual red blood cell population and the specifics of Rh and Kell antigen phenotyping using gel cards.

Gel card: signs of blood chimerism during red blood cell phenotyping
Gel card: signs of blood chimerism during red blood cell phenotyping

🩸 Blood Chimeras.

🙏 Photo courtesy of KDL biologist Yulia Guseva, Belorechenskaya Central District Hospital.

📖 Reference information: Blood chimerism is a condition in which two populations of red blood cells, differing in blood group or other antigens, are present in the bloodstream of a single organism. This phenomenon can arise as a result of cell exchange between fetuses in multiple pregnancies, after hematopoietic stem cell transplantation, or blood transfusion. The presence of chimeric populations is important to consider when interpreting laboratory results and selecting donor blood.