Hematology

LE Cells in Pleural Fluid in Drug-Induced Lupus

A rare clinical case: detection of lupus erythematosus (LE) cells in eosinophils of pleural fluid in drug-induced lupus erythematosus caused by carbamazepine.

Cytopreparation of pleural fluid: eosinophilic LE cells (indicated by arrows)
Cytopreparation of pleural fluid: eosinophilic LE cells (indicated by arrows)

🔬 Cytology. A rare case of LE cells in pleural fluid in a patient with drug-induced lupus.

The article in Diagnostic Cytopathology describes a unique case of lupus erythematosus cells (LE cells) found in the pleural fluid of a 74-year-old patient taking carbamazepine. Lupus erythematosus cells are usually represented by macrophages or neutrophils, but in this case, they were found in eosinophils, which is extremely rare in medical literature.

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Source of this case: Pérez‐Campos A. et al. Lupus erythematosus eosinophil cells in a pleural effusion //Diagnostic Cytopathology. – 2021. – Т. 49. – №. 3. – С. 454-456.