Oncohematology

Leukemization of B-cell Non-Hodgkin Lymphoma: Bone Marrow

A clinical case of B-NHL leukemization: 53% blasts in blood, 34.8% in bone marrow, high LDH, cytochemical analysis, and immunophenotyping.

🔬 Bone marrow cytology: 📌 Patient – male, considers himself ill since January 2025. 📌 Fever >39°C, dyspnea. 📌 CBC (February 2025): Hemoglobin 83 g/L Platelets 74 K/µL Leukocytes 24.99 K/µL (blasts 53%) 📌 Biochemistry: LDH 3126 U/L Ferritin 407.0 ng/mL CRP 276.6 mg/L 📌 Myelogram: BM cellularity: 34.0 ×10⁹/L Blasts 34.8% 🧬 Cytochemistry: Lipids detected in 1% of blast cells as a weakly positive reaction. Glycogen reaction positive in 51% of blast cells: finely granular - 38%, finely granular on diffuse - 10%, diffuse - 3%.

📌 Immunophenotyping: B-NHL. Leukemization.

🙏 Clinical case kindly provided by laboratory physician Yulia Kaliberda, Yekaterinburg.