Leukocytes in Urine Sediment: Morphology and Causes

Morphological features and detection of leukocytes in urine sediment: differentiation of neutrophils, factors of cell lysis, and clinical causes of leukocyturia.

Editorial team 1 min September 7, 2024

Native urine sediment preparation, accumulation of leukocytes with pronounced granularity

Urine sediment microscopy, scattered round leukocytes in the field of view

Native urine preparation, single leukocytes and a partially degenerated cell

Urine sediment microscopy, leukocytes with discernible granular cytoplasm

Native urine sediment preparation, leukocytes and a transitional epithelial cell

Urine sediment microscopy, leukocytes and a urothelial cell in a native preparation

Native urine preparation, leukocytes and an elongated urinary tract epithelial cell

Urine sediment microscopy, leukocytes against a background of amorphous detritus accumulation

🔬 Leukocytes in Urine Sediment ✅ Leukocytes are nucleated cells, larger than erythrocytes, with a diameter of about 8–15 microns. We can find both polymorphonuclear and mononuclear cells.

✅ Neutrophils are most commonly found during sediment examination; they can be distinguished by their granular cytoplasm and multi-lobed nucleus. Leukocytes can rapidly lyse in hypotonic and alkaline urine.

✅ The presence of leukocytes in urine can be due to various causes: infections, tumors, stones, or other pathologies affecting the urinary tract, systemic diseases, and medication intake.

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