Lab test interpretation

Macrophages in Synovial Fluid in Reactive Arthritis

Microscopic examination of synovial fluid in reactive arthritis: macrophage phagocytosis of neutrophils, diagnostic significance, and causes of inflammation.

Synovial fluid smear: macrophage that has phagocytosed a neutrophil (indicated by arrow)
Synovial fluid smear: macrophage that has phagocytosed a neutrophil (indicated by arrow)

Synovial fluid. A macrophage that has phagocytosed one or more neutrophils in a patient with reactive arthritis. This finding is not specific for reactive arthritis.

✅ Reactive arthritis is an inflammatory joint disease that manifests several days or weeks after a gastrointestinal or genitourinary infection. It is also described as the classic triad of arthritis, urethritis, and conjunctivitis. However, most patients do not exhibit the classic triad. Today, this disorder is considered to be caused by an abnormal autoimmune response to a gastrointestinal or genitourinary infection caused by Salmonella, Shigella, Campylobacter, or Chlamydia.

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