Hemostasis

Macrothrombocytes in Blood Smear: Morphology and Size

Morphology of macrothrombocytes and reticulated platelets in blood smears: size criteria, MPV values, and causes in destructive thrombocytopenia.

Blood smear: large macrothrombocytes against a background of erythrocytes
Blood smear: large macrothrombocytes against a background of erythrocytes

Macrothrombocytes (reticulated platelets). Reticulated platelets, sometimes called stress platelets, appear in destructive thrombocytopenia. Reticulated platelets are noticeably larger than normal mature circulating platelets; their diameter in peripheral blood smears exceeds 6 µm, and their MPV reaches 12-14 fL. Source: Elaine M. Keohane - Rodak’s hematology clinical principles and applications, fifth edition, 2016