Laboratory methods

p16 Marker in Immunocytochemistry of Cervical Neoplasms

The role of p16 protein in immunocytochemical diagnosis of cervical dysplasia (CIN) and cancer, its link to HPV E7 oncoprotein, and marker expression in tumor cells.

🔬 p16 Marker. Immunocytochemistry of Cervical Neoplasms. Educational material from the Department of Clinical Laboratory Diagnostics, RMACPE.

  • detected in the cytoplasm
  • kinase blocker, activating cell DNA synthesis
  • corresponds to the level of high-risk HPV E7 oncoprotein
  • Detected in dysplasia: CIN I in 30-60%, CIN II in 80-100%, CIN III up to 100%

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