Peripheral blood picture in beta-thalassemia after splenectomy: severe anisopoikilocytosis, target cells, normoblasts, and Howell-Jolly bodies.
👉🏻Severe anisopoikilocytosis in a patient with beta-thalassemia and splenectomy.
➖This is a hereditary blood disorder in which the synthesis of beta-globin chains is impaired.
🩸Peripheral blood
🔹The smear contains target cells (codocytes) characteristic of thalassemia (photo 1)
🔹Also, normoblasts (photos 1-3) and Howell-Jolly bodies (photo 4) are observed
🙏 The publication was kindly provided by clinical laboratory diagnostics physician Tanya Stepanova, Volgograd
Laboratory signs of warm autoimmune hemolytic anemia: microspherocytes, polychromasia, and normoblasts in blood smear, direct antiglobulin test.
Morphological criteria of proerythroblasts: nucleus structure, delicate reticular chromatin, nucleoli, and basophilic cytoplasm of erythroid cells.
Morphology of pathological erythrocyte inclusions: diagnostic significance of Cabot rings, Howell-Jolly bodies, basophilic stippling, and macrocytosis in blood smears.
