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Hematology

Megaloblastic Anemia in a Child: Cabot Rings in Blood Smear

Clinical case of anemia in a 1.5-year-old child: Cabot rings, pronounced basophilic stippling of erythrocytes, and macrocytosis in peripheral blood.

Anastasia Krasyuk Anastasia Krasyuk 1 min
Blood smear: normoblast, macrocytes, and pronounced anisocytosis
Blood smear: normoblast, macrocytes, and pronounced anisocytosis
Blood smear: erythrocyte with a Cabot ring in an oval shape
Blood smear: erythrocyte with a Cabot ring in an oval shape
Blood smear: erythrocyte with abundant basophilic stippling
Blood smear: erythrocyte with abundant basophilic stippling
Blood smear: basophilic granularity of an erythrocyte close-up
Blood smear: basophilic granularity of an erythrocyte close-up
Blood smear: normoblast and erythrocyte with a remnant of the mitotic spindle
Blood smear: normoblast and erythrocyte with a remnant of the mitotic spindle
Blood smear: Cabot rings in several erythrocytes
Blood smear: Cabot rings in several erythrocytes
Blood smear: macrocyte with a thin Cabot ring
Blood smear: macrocyte with a thin Cabot ring
Blood smear: basophilic stippling in the erythrocyte cytoplasm
Blood smear: basophilic stippling in the erythrocyte cytoplasm
Blood smear: multiple erythrocytes with basophilic granularity
Blood smear: multiple erythrocytes with basophilic granularity

👶 Child is 1.5 years old. 🔬 Cabot rings, macrocytes, basophilic stippling in erythrocytes, and…? 🩸 Blood test parameters: RBC (red blood cells): 3.18 × 10^12/L HGB (hemoglobin): 107.4 g/L (anemia) HCT (hematocrit): 28.1 % MCV (mean corpuscular volume): 88.5 fL MCH (mean corpuscular hemoglobin): 33.8 pg RDW-SD (red cell distribution width, standard deviation): 56.2 fL RDW-CV (red cell distribution width, coefficient of variation): 23 %

❓Presumptive diagnosis?

🙏 Images kindly provided by biologist Anastasia Krasyuk from Tambov

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