Morphological features of megaloblasts: loose nuclear chromatin and large cell size. Detection in megaloblastic anemia and myelodysplastic syndrome.
🔬Megaloblasts. Large nucleated red blood cells with abnormal “open” nuclear chromatin. They are often observed in the bone marrow in myelodysplastic syndrome or other megaloblastic anemia. They can also sometimes be seen in peripheral blood (1000×).
👉Source: McPherson - Henry’s Clinical Diagnosis and Management by Laboratory Methods, 24ed 2022
Morphological features of a binucleated megaloblast in bone marrow aspirate in pernicious anemia: chromatin structure and nuclear envelope.
Explore the morphology of megaloblasts in bone marrow aspirates from patients with vitamin B12 deficiency, focusing on asynchronous maturation, chromatin structure, and mitotic figures.
Cytological features of bone marrow aspirate: proerythroblast morphology with nucleoli, megaloblastic erythropoiesis, and binucleated megaloblasts in the smear.
