Diagram of mean corpuscular volume (MCV) changes. Pathogenesis of microcytosis and macrocytosis in iron deficiency, vitamin B12 deficiency, folate deficiency, and liver pathologies.
Mechanism of MCV changes in anemia, Stuart H. Ralston, 2022
Physiological hemoglobin elevation in smokers masks hidden iron deficiency. We examine WHO adjustments for accurate laboratory diagnosis of anemia.
Peripheral blood smear in vitamin B12 deficiency: severe macrocytosis with MCV 130 fL, megalocytes, poikilocytosis, and nucleated red blood cells.
A clinical case of severe macrocytic anemia: pancytopenia, MCV 121.5 fL, neutrophil hypersegmentation in blood smear, and differential diagnosis with MDS.
