Clinical cases

Metastatic Melanoma in Ascitic Fluid: Cytological Features

Cytological features of metastatic melanoma in ascitic fluid: atypical cells with nucleoli, melanin granules in cytoplasm and macrophages.

Cytological preparation of ascitic fluid: melanoma cells with pigment granules
Cytological preparation of ascitic fluid: melanoma cells with pigment granules

Metastatic melanoma in ascitic fluid. Tumor cells are discretely arranged, with abundant cytoplasm and eccentric oval nuclei containing prominent nucleoli. Characteristic melanin pigment (brown granules) is visible in the cytoplasm. The pigment is also phagocytosed by surrounding macrophages. Location: ascitic fluid.

Source: M. Sheaff, N. Singh – Cytopathology: An Introduction (2013).