⚠ Large cell neuroendocrine carcinoma metastasis to the bone marrow. 👉Following up on the post about bone marrow metastases, Anna Belen (a doctor from Israel🇮🇱) kindly sent us another case. ✅A 79-year-old male with pancytopenia in peripheral blood (analyzer photo below) and LDH 14930 U/L (reference interval: 230-480). ✅Mediastinal lymphadenopathy was also found during examination. ✅Preliminary diagnosis: lymphoproliferative disease. ✅Bone marrow aspiration failed; imprints were made from the trephine biopsy (photos below). ✅Histological conclusion from bone marrow biopsy: large cell neuroendocrine carcinoma. ✅Anna Belen advises in such cases, when doctors fail to obtain adequate material and when a hypocellular bone marrow is observed in the smear, to look for cell clusters at low magnification, especially along the edges of the smear, to detect malignant neoplasm cells.
Neuroendocrine Carcinoma Metastasis to Bone Marrow
A clinical case of large cell neuroendocrine carcinoma metastasis to the bone marrow: cytology of trephine biopsy imprints in pancytopenia.
